The table below summarizes the Wave 2 priority use cases and proposed pilot opportunities. Pilot activities and funding approaches are currently being developed in collaboration with CDC and are subject to change.

Use Case	Proposed Pilots
Chronic Disease	Create one standardized chronic care dataset that can be collected once through a trusted data intermediary and reused for STLT surveillance, HRSA UDS+ improvement, and NCQA/CMS-aligned digital measures. Additional work may focus on high-impact barriers to chronic disease control (transportation, food insecurity, housing) and tests bi-directional closed-loop outcomes through intermediary-enabled exchange.
Maternal Child Health	Create longitudinal datasets for health data from pregnancy through infancy. Additional work may include linking maternal and infant vital records to clinical history to improve speed and accuracy of surveillance.
Cancer Reporting	Use FHIR to automate reporting of cancer cases from EHRs to Cancer Registries. Use AI to assist with cancer case validation. Use HDU pre-filtering to reduce AIMS burden for cancer reporting. Enhance pathology-driven cancer reporting.
Biothreat Radar Detection	Leverage HIEs/HDUs to link BioThreat Radar-funded genomic data with clinical data for actionable surveillance information.

There will be no formal application process or cycle for Wave 2. If a state, local, or territorial public health agency is interested in one or more of the use cases described above, please email us at phdmic@astho.org and we will gauge alignment and eligibility on an individual basis.

The IC Program team will work with interested agencies to discuss program priorities, pilot opportunities, eligibility considerations, implementation readiness, and available funding and technical assistance support.